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The lung also has the additional challenge of being able to quickly change the components of the ELF to adapt to a constantly shifting composition of inhaled agents in the atmospheric environment

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Of the factors that participate in the TSS pathway, cystathionine beta-synthase (CBS) and cystathionine γ-lyase (CSE) mediate the first two rate-limiting steps of TSS by condensing serine with homocysteine to cystathionine and then cysteine